Differences in patterns of progression in demyelinating and axonal Guillain-Barré syndromes

作者: A. Hiraga , M. Mori , K. Ogawara , T. Hattori , S. Kuwabara

DOI: 10.1212/01.WNL.0000081231.08914.A1

关键词:

摘要: Background: Immune treatments are recommended for patients with Guillain–Barre syndrome (GBS) who cannot walk independently, but a considerable number of GBS in the progressive phase at first examination. Objective: To investigate whether progression patterns differ demyelinating and axonal subtypes GBS. Methods: Clinical, laboratory, electrophysiologic data on 131 consecutive were reviewed. Patients classified as having acute inflammatory polyneuropathy (AIDP) or motor neuropathy (AMAN) based electrodiagnostic criteria. Results: Forty-one had AIDP, 62 AMAN, 28 unclassified. Age, sex, Hughes Functional Grading Scale score medical examination did not AIDP AMAN patients. Mean periods between neurologic onset (5.3 vs 4.2 days; p = 0.01) nadir (18.0 11.5 0.001) longer group. In subgroup those mild disability (able to independently examination), 88% reached nadir, whereas 65% it. The remaining 35% progressed it over next 1 2 weeks unable nadir. Conclusions: speeds rapid an early frequently have significantly long after examination; therefore, they need be carefully monitored.

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