Two patterns of clinical recovery in Guillain-Barré syndrome with IgG anti-GM1 antibody

摘要: Objective: To investigate the prognostic value of anti-GM1 antibody. Background: Whether antibody is a marker poor prognosis due to axonal degeneration in Guillain-Barre syndrome (GBS) matter controversy. Methods: The clinical recovery 41 consecutive GBS patients was analyzed. Results: Hughes functional grading scores were similar at peak, and 1, 3, 6 months after onset for groups with (n = 19) without 22) immunoglobulin (Ig) G antibodies. However, anti-GM1-positive group included significantly higher proportions (inability walk independently months, 5 19 versus 0 22; p 0.01) those markedly rapid (improvement by two or more grades within month, 9 4 0.05). positivity IgG correlated well electrodiagnosis acute motor neuropathy pattern but not always associated prognosis. Anti-GM1-positive showed different patterns recovery-their conditions improved slower faster than anti-GM1-negative patients, most whom had inflammatory demyelinating polyneuropathy. Conclusions: Anti-GM1 and, besides degeneration, early reversible effects other demyelination could be part pathophysiology