Potential Social, Ethical, and Legal Issues Raised by the Development of Pharmacogenetics

Daniel J. Steward, Robert L. Haining, Kirk R. Henne, George Davis, Thomas H. Rushmore, William F. Trager, Allan E. Rettie, Genetic association between sensitivity to warfarin and expression of CYP2C9*3 Pharmacogenetics. ,vol. 7, pp. 361- 367 ,(1997) , 10.1097/00008571-199710000-00004

Ida Martinelli, Emanuela Taioli, Paolo Bucciarelli, Sepideh Akhavan, Pier Mannuccio Mannucci, Interaction Between the G20210A Mutation of the Prothrombin Gene and Oral Contraceptive Use in Deep Vein Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 700- 703 ,(1999) , 10.1161/01.ATV.19.3.700

Jun Imai, Ichiro Ieiri, Kohsuke Mamiya, Sayaka Miyahara, Hiroyasu Furuumi, Eiji Nanba, Masayuki Yamane, Yasuyuki Fukumaki, Hideaki Ninomiya, Nobutada Tashiro, Kenji Otsubo, Shun Higuchi, Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus. Pharmacogenetics. ,vol. 10, pp. 85- 89 ,(2000) , 10.1097/00008571-200002000-00011

Dennis J O’Kane, Richard M Weinshilboum, Thomas P Moyer, Pharmacogenomics and reducing the frequency of adverse drug events. Pharmacogenomics. ,vol. 4, pp. 1- 4 ,(2003) , 10.1517/PHGS.4.1.1.22588

Pieter W. Kamphuisen, Jeroen C. J. Eikenboom, Frits R. Rosendaal, Ted Koster, Andrew D. Blann, Hans L. Vos, Rogier M. Bertina, High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene British Journal of Haematology. ,vol. 115, pp. 156- 158 ,(2001) , 10.1046/J.1365-2141.2001.03089.X

C. Richards, R. Dingwall, A. Watson, Should NHS patients be allowed to contribute extra money to their care BMJ. ,vol. 323, pp. 563- 565 ,(2001) , 10.1136/BMJ.323.7312.563

Charles W. Francis, Bruce L. Davidson, Scott D. Berkowitz, Paul A. Lotke, Jeffrey S. Ginsberg, Jay R. Lieberman, Anne K. Webster, James P. Whipple, Gary R. Peters, Clifford W. Colwell Jr., Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial. Annals of Internal Medicine. ,vol. 137, pp. 648- 655 ,(2002) , 10.7326/0003-4819-137-8-200210150-00008

Su-Lan Wang, Jin-ding Huang, Ming-Derg Lai, Jing-Jane Tsai, Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese. Pharmacogenetics. ,vol. 5, pp. 37- 42 ,(1995) , 10.1097/00008571-199502000-00004

Juan Carlos Souto, Laura Almasy, Montserrat Borrell, Merce Garí, Elisabet Martínez, José Mateo, William H. Stone, John Blangero, Jordi Fontcuberta, Genetic determinants of hemostasis phenotypes in Spanish families. Circulation. ,vol. 101, pp. 1546- 1551 ,(2000) , 10.1161/01.CIR.101.13.1546

Patricia Danzon, Adrian Towse, The Economics of Gene Therapy and of Pharmacogenetics Value in Health. ,vol. 5, pp. 5- 13 ,(2002) , 10.1046/J.1524-4733.2002.51081.X