The ISCOMATRIX™ adjuvant

摘要: This chapter describes the immunostimulating complex, referred to as an “iscom” or ISCOM TM vaccine, a novel structure for antigenic presentation of membrane proteins from enveloped viruses with potent immunomodulatory capability. Since this discovery, many vaccines have been tested in animal models showing induction both humoral and cellular immune responses. ISCOMATRIX adjuvant is essentially same vaccine but without incorporated antigen. Antigens can be formulated produce providing antigen properties much broader application. Various more recently human clinical trials. All results date indicate that are safe well tolerated humans no vaccine-related serious adverse events laboratory abnormalities. capable inducing strong responses increases magnitude, speed, longevity responses, capacity dose reduction when compared other adjuvants such aluminum. The ability induce these broad due fact it effective delivery vehicle, which access MHC I II pathways, immunomodulator innate adaptive systems. Overall, make them viable candidates further development registration prophylactic therapeutic vaccines.