Studies on Isocyanides and Related Compounds. Synthesis of Oxazole Derivatives via the Passerini Reaction

作者: Ricardo Bossio , Stefano Marcaccini , Roberto Pepino

DOI: 10.1002/JLAC.1991199101193

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摘要: The reaction between arylglyoxals (1), cyclohexyl isocyanide, and aromatic carboxylic acids (2) affords N-cyclohexyl-2-acyloxy-3-aryl-3-oxopropionic amides (3) which can be cyclized to N-cyclohexyl-2,4-diaryl-5-oxazolecarboxamides (4).

参考文章(3)
Ricardo Bossio, Stefano Marcaccini, Roberto Pepino, A novel class of nitrile ylide Tetrahedron Letters. ,vol. 27, pp. 4643- 4646 ,(1986) , 10.1016/S0040-4039(00)85027-3
Stefano Marcaccini, Ricardo Bossio, Stefano Marcaccini, Robert Pepino, Synthesis of 5,5'-dialkoxy-2,2'-dioxazolylsulfides Heterocycles. ,vol. 24, pp. 2411- 2413 ,(1986) , 10.3987/R-1986-09-2411