Inactivation of Coxsackievirus B4, Feline Calicivirus and Herpes Simplex Virus Type 1: Unexpected Virucidal Effect of a Disinfectant on a Non-Enveloped Virus Applied onto a Surface
作者： Thomas Thevenin , Pierre Emmanuel Lobert , Didier Hober
DOI: 10.1159/000350556
关键词:
摘要: Objective: To evaluate the effect of a disinfectant onto viruses in suspension on one hand and applied surface other. Methods: A system combining flocked swabs to recover dried stainless steel carriers gel filtration eliminate cytotoxic products has been developed study virucidal quaternary ammonium-based towards herpes simplex virus type 1 (HSV-1), coxsackievirus B4 (CVB4) feline calicivirus F9 (FCV). The recovery FCV estimated by RT real-time PCR. Results: HSV-1, CVB4 had titer over 104 TCID50 · ml-1 after 2 h drying were recovered from using swabs. HSV-1 was inactivated (a reduction factor 4 2.83 log, respectively) whereas resistant. infectious moderate, 1.5 log 30 min, when suspension, it up 10 min carrier. Dried efficiently as demonstrated Conclusion: non-enveloped virus, FCV, surface, but not disinfectant. resistance disinfectants should be investigated further.
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