Inflammation and prostate cancer.

摘要: There is emerging evidence that prostate inflammation may contribute to prostatic carcinogenesis. Chronic has been associated with the development of malignancy in several other organs such as esophagus, stomach, colon, liver and urinary bladder. Inflammation thought incite carcinogenesis by causing cell genome damage, promoting cellular turnover, creating a tissue microenvironment can enhance replication, angiogenesis repair. Epidemiological data have correlated prostatitis sexually transmitted diseases an increased risk cancer intake anti-inflammatory drugs antioxidants decreased risk. Evidence from genetic molecular studies also support hypothesis and/or infection be cause cancer. In 1999 De Marzo et al proposed proliferative inflammatory atrophy (PIA) precursor PIN Further research will provide opportunities for discovery strategies treatment prevention