Erythrocyte and brain methionine adenosyltransferase activities in patients with schizophrenia.
作者： C. Gomes-Trolin , M. Yassin , C. G. Gottfries , B. Regland , B. Grenfeldt
关键词:
摘要: The activity of methionine adenosyltransferase (MAT) was investigated in erythrocytes and postmortem brain specimens (cortex gyrus frontalis, hippocampus thalamus) patients with schizophrenia treated neuroleptics. In comparison the control group, abnormally low values MAT Vmax an increased affinity towards (lower Km values) were found erythrocytes. brain, a regionally selective decrease cortex frontalis but however, unchanged. regions hippocampus, not thalamus, inversely correlated duration schizophrenia. rats for 28 days typical neuroleptic haloperidol atypical clozapine, significant increase corpus striatum. There is possibility that changes observed are attributed to medication.
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T. Sargent, L. Ismail, E.L. Dobson, M. Pollycove, Altered metabolism of the methionine methyl group in the leukocytes of patients with schizophrenia Biological Psychiatry. ,vol. 13, pp. 649- ,(1978)
G.L. Cantoni, J. Durell, Activation of methionine for transmethylation. II. The methionine-activating enzyme; studies on the mechanism of the reaction. Journal of Biological Chemistry. ,vol. 225, pp. 1033- 1048 ,(1957) , 10.1016/S0021-9258(18)64899-9
Laundy M, Bottiglieri T, Reynolds Eh, Godfrey P, Chary Tk, Carney Mw, Toone Bk, Transmethylation in depression. The Alabama journal of medical sciences. ,vol. 25, pp. 296- 301 ,(1988)
G.L. Cantoni, S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate. Journal of Biological Chemistry. ,vol. 204, pp. 403- 416 ,(1953) , 10.1016/S0021-9258(18)66148-4
Renato D. Alarcon, Lelland C. Tolbert, John A. Monti, Donna A. Morere, William G. Walter-Ryan, Beverly Kemp, John R. Smythies, One-carbon metabolism disturbances in affective disorders. A preliminary report. Journal of Affective Disorders. ,vol. 9, pp. 297- 301 ,(1985) , 10.1016/0165-0327(85)90060-6
Cecilia Gomes Trolin, Jonas Ekblom, Lars Oreland, Regulation of methionine adenosyltransferase catalytic activity and messenger RNA in SH-SY5Y human neuroblastoma cells Biochemical Pharmacology. ,vol. 55, pp. 567- 571 ,(1998) , 10.1016/S0006-2952(97)00514-5
Malak Kotb, Arthur M. Geller, Methionine adenosyltransferase: structure and function. Pharmacology & Therapeutics. ,vol. 59, pp. 125- 143 ,(1993) , 10.1016/0163-7258(93)90042-C
Cecilia Gomes Trolin, Charlotta Löfberg, Gustaf Trolin, Lars Oreland, Brain ATP:l-methionine S-adenosyltransferase (MAT), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH): regional distribution and age-related changes European Neuropsychopharmacology. ,vol. 4, pp. 469- 477 ,(1994) , 10.1016/0924-977X(94)90295-X
B. Regland, B. V. Johansson, C. -G. Gottfries, Homocysteinemia and schizophrenia as a case of methylation deficiency Journal of Neural Transmission. ,vol. 98, pp. 143- 152 ,(1994) , 10.1007/BF01277017
PATRICK BRACKEN, PATRICK COLL, Homocystinuria and schizophrenia. Literature review and case report. Journal of Nervous and Mental Disease. ,vol. 173, pp. 51- 55 ,(1985) , 10.1097/00005053-198501000-00008