Application of iPS cell-derived macrophages to cancer therapy
作者： Satoru Senju , Chihiro Koba , Miwa Haruta , Yusuke Matsunaga , Keiko Matsumura
DOI: 10.4161/ONCI.27927
关键词:
摘要: We established a method to produce large quantity of myeloid cells from human inducible pluripotent stem (iPSCs). When injected intraperitoneally into mice carrying peritoneal tumors, iPSC-derived (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection iPS-MCs expressing interferon β significantly inhibited the growth gastric and pancreatic cancers implanted in cavity immunocompromised mice.
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