Approaches to Palliative Therapies for Alzheimers Disease

摘要: Alzheimer's disease is a progressive neurodegenerative characterized by gradual and increasing loss of cognitive function behavioral abnormalities. The formation beta-amyloid plaques neurofibrillary tangles are recognized as the key pathologies disease. Changes in levels various neurotransmitters has been noted patients with may represent earliest biochemical casualty, preceding or signifying onset Over last 20 years number approaches to palliative treatment have scrutinized. majority effort focused on dysfunction, this initial debilitating symptom identification commercial development acetylcholinesterase inhibitors has, until recently, virtually dominated field, although efficacy demonstrated, clinical results suggest alternate warranted. This review will highlight those that improvement learning memory not disease-modifying strategies beta-amyloid, tau phosphorylation other hypotheses.