Effect of dose and time of melatonin injections on the diurnal rhythm of immunity in chicken.

摘要: Skwado-Solita K, Thaela M-J, GXuchowska B, Stepien D, Jagura M. Effect of dose and time melatonin injections on the diurnal rhythm immunity in chicken. J Pineal Res 1991: 10:3&35. Abstract: The effect daily immune parameters was examined White Leghorn cockerels, kept from hatching L:D 12:12 conditions. Subcutaneous were made at beginning darkness or 4 h earlier for four weeks starting one week life. The dosage group raised (10, 13, 16, 20 ng per bird daily, respectively) during consecutive weeks. two other doses 10 500 times higher increased every as well. Control birds received equivalent vehicle. Three-week-old chickens immunized ip with sheep red blood cells reimmunized later. Five-week-old sacrificed a 24 period h. existence evaluated by cosinor analysis. total white serum agglutinins more dependent than hormone used. level also sample collection. Results obtained indicate participation pineal gland regulation indices avian system function that exhibit changes sensitivity to exogenous melatonin.