Are human DNA tumour viruses involved in the pathogenesis of human neurogenic tumours

摘要: There are numerous reasons for assuming a participation of DNA viruses in the pathogenesis certain types human neurogenic tumours, although proof causal relationship is still missing. The observations and data can be summarized as follows: 1) many known animal transform cells vitro induce tumours (even transplacentally) animals, including primates. Some tumour highly neurooncogenic 2) viral becomes stably integrated into cell genome virus-induced experimental brain thus immortalized these cells 3) the analysis “morphological revertants” that resemble their non-tumour parent cells, demonstrates maintenance expression phenotype depend on presence viral genome 4) experimental very often closely counterparts terms histopathological electronmicroscopic features, biochemical properties, pattern behaviour metastasis 5) the question ubiquitous population, lead to persistent infections, cross anatomical barriers such bloodbrain barrier or placental barrier, either sporadically frequently involved CNS infections 6) some have been interpreted preliminary evidence an involvement oncogenic etiology tumours: existence common tumour-associated antigens; association HLA with tumours; higher incidence neoplasms individuals having received virus-contaminated vaccines; tumour-specific sequences which absent non-neoplastic tissues 7) tumour visualized isolated from neoplasms 8) virus-related neoantigens detected antibodies against found sera patients tumours 9) virus-related nucleic acid present majority studied, if sufficiently sensitive techniques applied, they normal tissues.