Molecular characteristics of hepatocellular carcinomas from different age groups.

摘要: While most patients in Western countries who are diagnosed with HCC their 50s and 60s, HCCs at extremes of the age spectrum (i.e., < 40 years ≥ 75 years) less common have been linked distinct geographic locations etiologies. Using multiplatform profiling, we identified differences genetic alterations protein expression different groups within a large cohort (N = 421). Young adult (18-39 years' old) were more likely to be female, living West Midwestern United States, showed decreased androgen receptor, drug resistance pro-angiogenic compared older patients. TP53 mutations frequent alteration young adults (19%), whereas CTNNB1 occurred 30-33% old. The overall frequency pathogenic presumed was observed increase significantly advancing age. To our knowledge, these data represent one only studies analyze age-specific molecular profiles HCC, provide basis for further exploration validation findings respect clinical therapeutic implications.