摘要: The properties of human glia and glioma cells in culture are reviewed. Glia-like from non-neoplastic brain show all accepted hallmarks normalcy: limited life span, low terminal cell density, strong density dependent inhibition proliferation, diploidy contact membrane mobility. Twenty five lines have been studied. They showed infinite increased relaxed aneuploidy deficient So far attempts to explain these departures normal on the basis a single metabolic defect failed. Instead, tested shown an individual mosaic structural and/or abnormalities characteristic for each line. This was particulary well demonstrated studies glycosaminoglykans. possibility is discussed that malignant phenotype can rise exist almost number ways. essential feature may be acquisition growth potential which will set stage multiplication genetic variants with ever increasing fitness proliferation spread.
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