Selection Between Liver Resection Versus Transarterial Chemoembolization in Hepatocellular Carcinoma: A Multicenter Study.

摘要: Objectives Models should be developed to assist choice between liver resection (LR) and transarterial chemoembolization (TACE) for hepatocellular carcinoma. Methods After separating 520 cases from 5 hospitals into training (n = 302) validation 218) data sets, we weighted the control baseline difference ensured causal effect treatments (LR TACE) estimated progression-free survival (PFS) difference. A noninvasive PFS model was constructed with clinical factors, radiological characteristics, radiomic features. We compared our other 4 state-of-the-art models. Finally, patients were classified subgroups without significant treatments. Results Our included treatments, age, sex, modified Barcelona Clinic Liver Cancer stage, fusion lesions, carcinoma capsule, 3 features, good discrimination calibrations (area under curve 3-year 0.80 in set 0.75 set; similar results achieved 1- 2-year PFS). The had better accuracy than nomogram built, different scores assigned LR TACE. Separated by threshold of score some patients, provided longer might option (training: hazard ratio [HR] 0.50, P 0.014; validation: HR 0.52, 0.026); others, TACE 0.84, 0.388; 1.14, 0.614). may because it less invasive. Discussion propose an individualized predicting optimal treatment choice.