Plasma S/R ratio of warfarin co-varies with VKORC1 haplotype

L S Kaminsky, M J Coon, M J Fasco, K P Vatsis, Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver. Journal of Biological Chemistry. ,vol. 253, pp. 7813- 7820 ,(1978) , 10.1016/S0021-9258(17)34443-5

M. B. Faletto, J. A. Goldstein, L. S. Kaminsky, S. M. F. De Morais, D. A. Dunbar, Correlation of human cytochrome P4502C substrate specificities with primary structure : warfarin as a probe Molecular Pharmacology. ,vol. 43, pp. 234- 239 ,(1993)

Simone Rost, Andreas Fregin, Vytautas Ivaskevicius, Ernst Conzelmann, Konstanze Hörtnagel, Hans-Joachim Pelz, Knut Lappegard, Erhard Seifried, Inge Scharrer, Edward G. D. Tuddenham, Clemens R. Müller, Tim M. Strom, Johannes Oldenburg, Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2 Nature. ,vol. 427, pp. 537- 541 ,(2004) , 10.1038/NATURE02214

Abdimajid Osman, Kerstin Arbring, Tomas L. Lindahl, A new high-performance liquid chromatographic method for determination of warfarin enantiomers. Journal of Chromatography B. ,vol. 826, pp. 75- 80 ,(2005) , 10.1016/J.JCHROMB.2005.08.011

Keiko Maekawa, Hiromi Fukushima-Uesaka, Masahiro Tohkin, Ryuichi Hasegawa, Hiroshi Kajio, Nobuaki Kuzuya, Kazuki Yasuda, Manabu Kawamoto, Naoyuki Kamatani, Kazuko Suzuki, Tatsuo Yanagawa, Yoshiro Saito, Jun-ichi Sawada, Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese Pharmacogenetics and Genomics. ,vol. 16, pp. 497- 514 ,(2006) , 10.1097/01.FPC.0000215069.14095.C6

Christof Geisen, Matthias Watzka, Katja Sittinger, Michael Steffens, Laurynas Daugela, Erhard Seifried, Clemens R. Müller, Thomas F. Wienker, Johannes Oldenburg, VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation Thrombosis and Haemostasis. ,vol. 94, pp. 773- 779 ,(2005) , 10.1160/TH05-04-0290

Craig R. Lee, Joyce A. Goldstein, John A. Pieper, Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics. ,vol. 12, pp. 251- 263 ,(2002) , 10.1097/00008571-200204000-00010

Daniel J. Steward, Robert L. Haining, Kirk R. Henne, George Davis, Thomas H. Rushmore, William F. Trager, Allan E. Rettie, Genetic association between sensitivity to warfarin and expression of CYP2C9*3 Pharmacogenetics. ,vol. 7, pp. 361- 367 ,(1997) , 10.1097/00008571-199710000-00004

M Wadelius, L Y Chen, K Downes, J Ghori, S Hunt, N Eriksson, O Wallerman, H Melhus, C Wadelius, D Bentley, P Deloukas, Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics Journal. ,vol. 5, pp. 262- 270 ,(2005) , 10.1038/SJ.TPJ.6500313

Harumi Takahashi, Grant R. Wilkinson, Edith A. Nutescu, Takashi Morita, Marylyn D. Ritchie, Maria G. Scordo, Vittorio Pengo, Martina Barban, Roberto Padrini, Ichiro Ieiri, Kenji Otsubo, Toshitaka Kashima, Sosuke Kimura, Shinichi Kijima, Hirotoshi Echizen, Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans Pharmacogenetics and Genomics. ,vol. 16, pp. 101- 110 ,(2006) , 10.1097/01.FPC.0000184955.08453.A8