Dimethyl fumarate protection against collagen II degradation
作者： Ye Li , Jie Tang , Yong Hu
DOI: 10.1016/J.BBRC.2014.10.005
关键词:
摘要: Degradation of collagen type II caused by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) is one the major pathological characteristics osteoarthritis (OA). Dimethyl fumarate (DMF) a medication approved US Food and Drug Administration (FDA) an oral multiple sclerosis (MS) therapy. In this study, we found that DMF ameliorated degradation inhibiting expression MMP-1, MMP-3, MMP-13 TNF-α. Mechanistically, attenuated MMPs suppressing JAK/STAT3 pathway. These findings imply treatment might be potential therapeutic strategy for chondroprotective
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