Adversomics: the emerging field of vaccine adverse event immunogenetics.

摘要: Vaccines have enabled tremendous decreases in infectious diseases, eradication of smallpox, saved lives, and remain among the most effective cost-effective our public health initiatives.1 At same time, as an ever larger number vaccines are administered globally, increasing concerns about adverse events reactions been raised threaten successes attributable to vaccines. For example, controversy surrounding measles-mumps-rubella (MMR) vaccine thimerosal emblematic perceptions regarding safety (AEs). With current future technologic advances such high throughput whole-genome scanning, transcriptomics, epigenetics, proteomics, new biostatistical approaches understanding huge databases information, we can better understand associations mechanisms by which genetically-mediated individual variations response reactivity occur. Armed with knowledge, ability predict AEs, or design that minimize eliminate serious vaccine-related could be devised, consistent a more personalized approach practice called adversomics (the immunogenetics immunogenomics at population level, respectively).