Bone Marrow Failure in Children With Acute Liver Failure

摘要: Background Aplastic anemia is a rare but well-recognized complication of acute hepatitis and liver failure. The cause unknown, the condition fatal without bone marrow recovery. Treatment includes immunosuppression regimens or transplantation. purpose this study was to investigate incidence, cause, treatment, outcomes disorder in children. Methods Retrospective chart review 75 patients with failure major pediatric center. Results Eight had evidence Of those, six aplastic anemia, two transient suppression. There were five boys, median age 57 months (range, 36-132 months). Two parvovirus B19, non-A, non-B, non-C hepatitis. Five underwent transplantation: auxiliary one, orthotopic four. interval between initial symptoms development and/or suppression 21 99 days (median, 39 days). Four received intravenous antithymocyte globulin (ATG) antilymphocyte (ALG). Median recovery period granulopoiesis 62 27-115 made full recovery, one myelodysplasia, unresponsive disease died septic complications. did not receive ATG/ALG, Three transplantation, all four resumed granulopoiesis. One child who transplantation sepsis chronic rejection. 20-153 Conclusions Bone occurs 10.7% children It sometimes association B19 infection. ATG/ALG successful well tolerated most cases.