Liver transplantation in children with metabolic diseases: The studies of pediatric liver transplantation experience

摘要: Arnon R, Kerkar N, Davis MK, Anand Yin W, Gonzalez-Peralta RP for the SPLIT Research Group. Liver transplantation in children with metabolic diseases: The studies of pediatric liver experience. Pediatr Transplantation 2010: 14:796–805. © 2010 John Wiley & Sons A/S. Abstract:  Metabolic diseases are second largest indication LT after BA. There limited data on long-term post-transplant outcome this unique group patients. Therefore, our aim was to assess post-liver transplant outcomes and evaluate risk factors mortality graft loss disorders comparison those non-metabolic diagnoses. We reviewed all patients enrolled registry. Between 1995 2008, 446 2997 (14.9%) underwent diseases. One-yr five-yr patient survival 94.6% 88.9% other 90.7% 86.1% (log-rank p = 0.05), respectively. 90.8% 83.8%, 85.4% 78.0% p = 0.005), Children were less likely experience gastrointestinal complications (5.6% vs. 10.7%, p = 0.001), portal vein thrombosis (2.9% 5.2%, p = 0.04), reoperations within 30 days (33.4% 37.8%, p = 0.05) than indications. In conclusion, who disease had similarly excellent as, better than, received a allograft