Liver transplantation for childhood hepatic malignancy: a review of the United Network for Organ Sharing (UNOS) database

摘要: Abstract Background Orthotopic liver transplantation (OLT) is the only treatment option for unresectable hepatoblastoma (HB) and hepatocellular carcinoma (HCC) in children. Aggregated outcomes of OLT these hepatic malignancies have not been evaluated United Network Organ Sharing national database. Purpose The purpose this study was to evaluate graft patient survival pediatric recipients with HB HCC. Methods Data from Standard Transplant Research Files were analyzed included ( χ 2 tests, as appropriate. Actuarial effect diagnosis on determined using Kaplan-Meier methods log-rank tests. Results Since 1987, 152 OLTs performed 135 patients 43 41 Respective 1-, 5-, 10-year after 79%, 69%, 66% 86%, 63%, 58% HCC P = .73). primary cause death both groups metastatic or recurrent disease, accounting 54% deaths group 86% .338). Patients younger (mean age, 2.9 ± 2.5 vs 10.4 4.8 years group; .03). A greater proportion had previous abdominal surgery than (63% 37% HCC, .04). Pretransplant medical condition transplant era associated univariate multivariate analysis (all Conclusions remains a viable results good long-term survival. an important predictor outcome. Thus, conjunction better chemotherapy regimens, earlier evaluation may result yet further improved