Synthesis of a new series of 2-(2-oxo-2 H -chromen-3-yl)-5 H -chromeno[4,3- b ]pyridin-5-ones by two facile methods and evaluation of their antimicrobial activity

摘要: A series of novel 2-(2-oxo-2H-chromen-3-yl)-5H-chromeno[4,3-b]pyridin-5-ones 4a–4l have been synthesized using two methodologies (using Mannich base 4-hydroxy coumarin and 4-chloro-3-formyl coumarin) (Patel et al., 2012) assayed for their antibacterial activity against gram-positive bacteria viz. Bacillus subtilis (MTCC 441), Staphylococcus aureus 96) gram-negative Escherichia coli 443), Salmonella typhimurium 98). The compounds were also antifungal Aspergillus niger 282) Candida albicans 227). All the exhibited potent inhibitory compared to standard drugs at tested concentrations. showed appreciable as well fungi. 4e, 4f, 4i, 4k, 4l are found be most proficient members emerged potential molecules further development.