Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway
作者： Yen-Hua Chen , Radomir Kratchmarov , Wen-Hsuan W. Lin , Nyanza J. Rothman , Bonnie Yen
DOI: 10.1016/J.CELREP.2017.12.087
关键词:
摘要: Summary Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric becomes organized is not understood. We show that receptor-associated class I phosphatidylinositol 3-kinase (PI3K) activity, indexed by (3,4,5)-trisphosphate (PIP 3 ) staining, spatially restricted to the microtubule-organizing center and subsequently one pole mitotic spindle in activated T B lymphocytes. Asymmetric PI3K activity co-localizes with polarization antigen receptor components implicated facultative glucose transporters whose trafficking dependent abundance marks cells destined for differentiation. Perturbation disrupts asymmetry upstream receptors downstream transporter traffic. The roles nutrient utilization, proliferation, gene expression may have converged conserved role cellular symmetry breaking form a logic regenerative lymphocyte divisions.
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