DNA repair genes polymorphism and lung cancer risk with the emphasis to sex differences
作者： L. Letkova , T. Matakova , L. Musak , M. Sarlinova , M. Krutakova
DOI: 10.1007/S11033-013-2626-Z
关键词:
摘要: Polymorphisms in nucleotide and base excision repair genes are associated with the variability risk of developing lung cancer. In present study, we investigated polymorphisms following selected DNA genes: XPC (Lys939Gln), XPD (Lys751Gln), hOGG1 (Ser326Cys) XRCC1 (Arg399Gln), risks they towards development cancer emphasis to gender differences within Slovak population. We analyzed 761 individuals comprising 382 patients diagnosed 379 healthy controls. Genotypes were determined by polymerase chain reaction/restriction fragment length polymorphism method. found out statistically significant increased for between genders. Female carrying Gln/Gln, Lys/Gln+Gln/Gln Arg/Gln, Arg/Gln+Gln/Gln genotypes had significantly corresponding OR = 2.06; p = 0.04, OR = 1.66; p = 0.04 OR = 1.62; OR = 1.69; p = 0.02 respectively. total, was combinations genotypes: Lys/Gln+XPC Lys/Lys (OR = 1.62; p = 0.04), Gln/Gln+hOGG1 Ser/Ser (OR = 2.14; p = 0.02). After stratification genders, genotype be male: (OR = 1.87; p = 0.03), Arg/Gln+XPC (OR = 4.52; p = 0.0007), Lys/Gln (OR = 5.44; p < 0.0001). female, different significant: Arg/Gln+hOGG1 (OR = 1.98; (OR = 3.75; p = 0.02), (OR = 2.40; Gln/Gln (OR = 3.03; p = 0.04). decreased female controls: Lys/Lys+XPC (OR = 0.45; (OR = 0.32; p = 0.005), (OR = 0.48; Our results did not show any difference pooled smokers non-smokers observed gene association risk. However, indicated possible effect heterozygous constitution (Ser/Cys) on (OR = 0.20; p = 0.01) (Lys/Gln) male (OR = 2.70; p = 0.01).
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