Effects of chronic insufficiency of drinking water in white mice.

摘要: Previous dehydration studies have emphasized almost exclusively acute in white rats or larger laboratory mammals. There is little information on rodents smaller than rats, the effects of chronic any sized mammal. In order to study uncomplicated by other changes, such as starvation, it may be necessary cause water loss quickly— forced diuresis (see Brokaw, 1949) extrarenal exposure heat (Adolph, 1947). But, pointed out an animal's response and toleration a rapidly developing quite different from that slowly occurring loss. There are fairly numerous reports casual, limited observations general deficiency small wild review Schmidt-Nielsen, 1952), but there been few serious studies. The latter include survival time reduced rations (Lindeborg, measurement energy metabolism exchanges extremely intakes (Chew, 1951), balance kidney function air-dry diets (Schmidt-Nielsen, 1952). Changes blood compartments mice restricted unexplored field. The physiological inadequate intake excessive varied: starvation 1947; 1949), reduction volume, with edema (Dicker, without 1947), failure renal responsiveness load concentration body fluids (Black et al. , 1944), cell (Winkler 1944). Death occur during has attributed circulatory collapse 1944; others), not although mentioned complication. The object present …