Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia

摘要: Genital human papillomavirus (HPV) infection is the major causal factor of cervical intraepithelial neoplasia (CIN). The potential role nutrition as an additional, independent risk for CIN has not been appropriately addressed in context HPV. This case-control study evaluated etiologic HPV terms viral type and load examined association between plasma levels micronutrients adjusting Cases (n 5 378) with histo-pathologically confirmed controls 366) no history abnormal Pap smears were recruited from colposcopy gynecology clinics, respectively. Risk was significantly increased among women who infected multiple types (odds ratio [OR] 21.06), a high (OR 13.08) 16 62.49). After positivity demographic factors, there inverse correlation a-tocopherol 0.15). Plasma ascorbic acid protective at level H 0.803 mg/dl 0.46). associated retinol b-carotene levels. effect genital on development highly influenced by oncogenic load. Vitamins C E may play that needs to be prospective studies. Int. J. Cancer 78:594‐599, 1998. r 1998 Wiley-Liss, Inc.