Sexual dimorphism in the induction of LTP: critical role of tetanizing stimulation.

摘要: Numerous studies have suggested that sexual dimorphism may exist in learning and memory, particularly types involving the hippocampus. In present study, we examined effects of two different tetani on induction long-term potentiation CA1 region hippocampal slices from adult female male rats to determine differences their responses tetanizing stimulation. We found LTP is sex-dependent, there were clear tetanus patterns, but not impulse number or stimulation frequency. Multiple trains more effective indution than ones. These findings suggest can react a broader range compared with rats. Based our results other studies, propose interaction gonadal hormones Ca2+/NMDAR subsequent regulation ERK/MAP kinase pathway are critical mechanisms for LTP.