Temporal and Hippocampal Metabolic Rate During an Olfactory Memory Task Assessed by Positron Emission Tomography in Patients With Dementia of the Alzheimer Type and Controls

作者: Monte S. Buchsbaum

DOI: 10.1001/ARCHPSYC.1991.01810330064010

关键词:

摘要: • Positron emission tomography with fludeoxyglucose F 18 was used to assess cortical metabolic rate during an olfactory memory task in six patients dementia of the Alzheimer type. Metabolic activity compared that both agematched controls performing and resting their eyes closed. Patients had lower rates anterior portion medial-temporal cortex than did controls, difference greatest between task. This region is known receive a large input has been implicated encoding human memory. Normal closed significantly this area when normal Our results are consistent those earlier reports temporal lobe decreases extend them through examination areas salient behavioral loss.

参考文章(37)
M. B. Brown, Wilfrid Joseph Dixon, BMDP statistical software University of California Press. ,(1983)
Joseph Hanaway, Melville Roberts, Atlas of the human brain in section ,(1970)
E G McGeer, D K Li, M J Adam, R Harrop, P L McGeer, H Kamo, H Tuokko, B L Beattie, W Ammann, D B Calne, Positron emission tomography in patients with clinically diagnosed Alzheimer's disease Canadian Medical Association Journal. ,vol. 134, pp. 597- 607 ,(1986)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
S. C. Huang, M. E. Phelps, E. J. Hoffman, K. Sideris, C. J. Selin, D. E. Kuhl, Noninvasive determination of local cerebral metabolic rate of glucose in man American Journal of Physiology-endocrinology and Metabolism. ,vol. 238, ,(1980) , 10.1152/AJPENDO.1980.238.1.E69
C Gentes, Y Yonekura, B Reisberg, M J de Leon, A P Wolf, M Emmerich, A E George, J Brodie, J S Fowler, D R Christman, S H Ferris, B Gee, I I Kricheff, Positron emission tomographic studies of aging and Alzheimer disease. American Journal of Neuroradiology. ,vol. 4, pp. 568- 571 ,(1983)
Robert P. Friedland, Thomas F. Budinger, Elisabeth Koss, Beth A. Ober, Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization Neuroscience Letters. ,vol. 53, pp. 235- 240 ,(1985) , 10.1016/0304-3940(85)90543-9
Monte S. Buchsbaum, Joseph C. Wu, Lynn E. DeLisi, Henry H. Holcomb, Erin Hazlett, Katharine Cooper-Langston, Robert Kessler, Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: Differences between normal controls and schizophrenic patients Biological Psychiatry. ,vol. 22, pp. 479- 494 ,(1987) , 10.1016/0006-3223(87)90170-3
C. A. Tamminga, N. L. Foster, P. Fedio, E. D. Bird, T. N. Chase, Alzheimer's disease: Low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism Neurology. ,vol. 37, pp. 161- 161 ,(1987) , 10.1212/WNL.37.1.161
H. Braak, E. Braak, P. Kalus, Alzheimer's disease: areal and laminar pathology in the occipital isocortex. Acta Neuropathologica. ,vol. 77, pp. 494- 506 ,(1989) , 10.1007/BF00687251