Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities
作者： A. Gonzalez-Quintela , R. Alende , F. Gude , J. Campos , J. Rey
DOI: 10.1111/J.1365-2249.2007.03545.X
关键词:
摘要: The present study investigated serum immunoglobulin (Ig) concentrations in relation to demographic factors, common habits (alcohol consumption and smoking) metabolic abnormalities an adult population-based survey including 460 individuals. Serum levels of interleukin (IL)-6, a marker inflammation, were also determined. After adjusting for confounders, male sex was associated positively with IgA negatively IgM levels. Age IgG Smoking Heavy drinking Metabolic (obesity syndrome) Abdominal obesity hypertriglyceridaemia the components syndrome most strongly IgA. drinkers showed particularly high IL-6 correlated concentrations. It is concluded that sex, age, alcohol consumption, smoking should be taken into account when interpreting IgA, IgM.
sci-hub.se 参考文章(51)
L.M Browning, J.D Krebs, S.A Jebb, Discrimination ratio analysis of inflammatory markers: implications for the study of inflammation in chronic disease. Metabolism-clinical and Experimental. ,vol. 53, pp. 899- 903 ,(2004) , 10.1016/J.METABOL.2004.01.013
EMANUELA CECCHIN, SERGIO DE MARCHI, Alcohol misuse and renal damage. Addiction Biology. ,vol. 1, pp. 7- 17 ,(1996) , 10.1080/1355621961000124656
C. GLUUD, U. TAGE-JENSEN, Autoantibodies and immunoglobulins in alcoholic steatosis and cirrhosis Acta Medica Scandinavica. ,vol. 214, pp. 61- 66 ,(2009) , 10.1111/J.0954-6820.1983.TB08571.X
E. J. Giltay, J. C. M. Fonk, B. M. E. von Blomberg, H. A. Drexhage, C. Schalkwijk, L. J. G. Gooren, In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans. The Journal of Clinical Endocrinology and Metabolism. ,vol. 85, pp. 1648- 1657 ,(2000) , 10.1210/JCEM.85.4.6562
Angela Dispenzieri, Morie A. Gertz, Terry M. Therneau, Robert A. Kyle, Retrospective cohort study of 148 patients with polyclonal gammopathy Mayo Clinic Proceedings. ,vol. 76, pp. 476- 487 ,(2001) , 10.4065/76.5.476
Anna Mae Diehl, Obesity and alcoholic liver disease Alcohol. ,vol. 34, pp. 81- 87 ,(2004) , 10.1016/J.ALCOHOL.2004.07.010
Bhawna Singh, V. Mallika, Binita Goswami, WITHDRAWN: Metabolic syndrome: Diagnosis, potential markers and management—an update Clinica Chimica Acta. ,(2006) , 10.1016/J.CCA.2006.08.031
Jaana Latvala, Johanna Hietala, Heidi Koivisto, Kimmo Jarvi, Petra Anttila, Onni Niemela, Immune Responses to Ethanol Metabolites and Cytokine Profiles Differentiate Alcoholics with or without Liver Disease. The American Journal of Gastroenterology. ,vol. 100, pp. 1303- 1310 ,(2005) , 10.1111/J.1572-0241.2005.41509.X
Susan K. Fried, Dove A. Bunkin, Andrew S. Greenberg, Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 847- 850 ,(1998) , 10.1210/JCEM.83.3.4660
Paul S. Horn, Amadeo J. Pesce, Reference intervals: an update Clinica Chimica Acta. ,vol. 334, pp. 5- 23 ,(2003) , 10.1016/S0009-8981(03)00133-5