Retrospective cohort study of 148 patients with polyclonal gammopathy

摘要: Objective To quantify clinical conditions and laboratory values associated with moderate to marked polyclonal gammopathy. Patients Methods Patient characteristics, correlates, evolving disease states, survival of all patients seen at the Mayo Clinic, Rochester, Minn, during 1991 a gamma globulin level 3.0 g/dL or higher were reviewed in this retrospective cohort study. Results One hundred forty-eight identified (median age, 58 years; 59% female). In 130 (88%), only 1 diagnosis was identified. Liver most common single association 79 (61%) patients, followed by connective tissue diseases 28 (22%), chronic infections 8 (6%), hematologic disorders 6 (5%), nonhematologic malignancies 4 (3%). No difference levels existed between groups. With median follow-up 67 months, 90 (63%) 143 for whom available alive. By multivariate analysis, albumin concentration, group, platelet count predictive survival. patient developed myeloma clonal plasmaproliferative disorder. Conclusion Moderate gammopathy may reflect an underlying condition: liver disease, disorder, infection, malignancy.