The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps

作者: PAUL N. MANSON , ROBERT M. ANTHENELLI , MICHAEL J. IM , GREGORY B. BULKLEY , JOHN E. HOOPES

DOI: 10.1097/00000658-198307000-00017

关键词:

摘要: The contribution of free radical-mediated reperfusion injury to the ischemic damage caused by total venous occlusion island skin flaps was investigated in a standardized rat model. Control subjected 8 hours showed complete, full thickness necrosis when followed for 7 days following release vascular occlusion. Treatment with superoxide dismutase, scavenger radicals, prior and immediately onset reperfusion, significantly enhanced flap survival from 0/11 (0%) 8/15 (53%), p less than 0.005, 0/9 6/12 (50%), 0.02, respectively. These findings are consistent hypothesis that oxygen radicals generated at time period ischemia contribute ultimate injury. Such similar reported observations on other tissues suggest means which tissue might be therapeutically modified, even after ischemia.

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