A newly developed hydroxyl radical scavenger, EPC-K1 can improve the survival of swine warm ischemia-damaged transplanted liver grafts.

摘要: Using a swine orthotopic liver transplantation (SOLTx) model, we assessed the effect of new hydroxyl radical scavenger EPC-K1 on warm ischemic damage graft and recipient survival. Animals were divided into 5 groups. The first group (control 1) consisted pigs which not operated but served as controls for indocianine green disappearance rate (K-ICG) determinations. In second 2), 10 livers transplanted without ische­ mia (WI) K-ICGvalues measj.lred. third 3) was main control study groups transplants with 30 min WI any special treatment. fourth fifth 1 2. Five trans­ plants carried out in each group, 3. recipients treated an additional5 mg/kg i. v. 2 20 EPC-Kl. Significant improvement glu­ tamic oxaloacetic transaminase (GOT) lactate dehy­ drogenase (LDH) levels, K-ICG values histological findings observed intravenous administration this agent had strong protective after could significantly prolong reci­ pient