Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada.

摘要: As part of the SEARCH Collaborating Study Group International Agency for Research on Cancer (IARC), a population-based case-control study cancer pancreas was conducted in Montreal, interviewing 179 patients and controls matched age, sex, language (French) selected by modified random-digit dialing method. Results showed positive strong association between cigaret smoking pancreatic cancer. Total fat, particularly saturated cholesterol consumption excess energy derived from fat were associated with risk; dietary fiber intake, retinol equivalent, β-carotene, vitamin C, calcium inverse risk. History such medical conditions as constipation, gallbladder problems, diabetes also found to be More important, 7.8% reported family history same disease, compared 0.6% among controls, 13-fold difference cases controls. Within original further instances familial conducted, based 14 56 The results support finding main study, there no apparent differences environmental-risk-factor profile nonfamilial cases. This unusual aggregation French Canadians cannot explained environmental factors alone. Some predisposition (hereditary factors) may play an important role etiology this cancer, at least region. findings suggest potential importance conducting genetic studies