Effect of structural modification on photodynamic activity of hypocrellins.
作者： Jianghua Ma , Jingquan Zhao , Lijin Jiang
DOI: 10.1562/0031-8655(2001)074<0143:EOSMOP>2.0.CO;2
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摘要: Abstract Aluminum ion complexed 5,8-di-Br-hypocrellin B is a new water-soluble perylenequinonoid derivative with enhanced absorption over hypocrellin (HB) in the phototherapeutic window (600–900 nm). Electron paramagnetic resonance and 9,10-diphenyl-anthracene bleaching methods were used to investigate photosensitizing activity of [Al2(5,8-di-Br-HB)Cl4]n presence oxygen. Singlet oxygen, superoxide anion radical hydroxyl can be generated by photosensitization. oxygen (1O2) formed via energy transfer from triplet-state ground-state molecular 1O2 participates generation portion (O2·−). Besides (O2·−) may originate electron between ·OH through Fenton–Haber–Weiss reaction decomposition DMPO–1O2 adduct. Compared HB [Al2(5,8-...
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