Studies on the chelation of hypocrellin A with aluminium ion and the photodynamic action of the resulting complex
作者： Yi-Zhen Hu , Jing-Yi An , Li-Jin Jiang (Li-Chin Chiang)
DOI: 10.1016/1011-1344(93)06973-7
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摘要: Abstract Hypocrellin A (HA), a perylenoquinone derivative, is an efficient phototherapeutic agent. The chelation of HA with aluminium ion (Al3+) results in the formation 1:1 complex (Al3+-HA). probable structure for this has been proposed. Compared HA, much higher solubility water. In addition, Al3+-HA preserves 1O2-generating function as demonstrated by diphenylanthracene photobleaching experiments. irradiated oxygen-saturated solutions superoxide radical anion and hydroxyl are formed verified using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) electron spin resonance (ESR) trapping production enhanced significantly presence donors such 1-benzyl-1,4-dihydronicotinamide (BNAH). These suggest that photodynamic action proceeds via both type 1 2 reactions.
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