Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study

作者: Fei Ma , Heyong Huang , Xuefeng Ge , Xiaodi Yang , Chao Yang

DOI: 10.1016/J.BMCL.2013.01.059

关键词:

摘要: The complex of Hypocrellin A with Al(3+) is prepared in water solution by a facile method. water-solubility and stability complexes are improved. Irradiation Al(3+)-HA results higher efficient generation singlet oxygen ((1)O2) photocleavage ability to CT DNA than HA. In vitro studies have illustrated that the has anti-cancer activity.

参考文章(21)
Yi-Zhen Hu, Jing-Yi An, Li-Jin Jiang (Li-Chin Chiang), Studies on the chelation of hypocrellin A with aluminium ion and the photodynamic action of the resulting complex Journal of Photochemistry and Photobiology B: Biology. ,vol. 22, pp. 219- 227 ,(1994) , 10.1016/1011-1344(93)06973-7
Lin Zhou, Huijun Jiang, Shaohua Wei, Xuefeng Ge, Jiahong Zhou, Jian Shen, High-efficiency loading of hypocrellin B on graphene oxide for photodynamic therapy Carbon. ,vol. 50, pp. 5594- 5604 ,(2012) , 10.1016/J.CARBON.2012.08.013
Seyed Mohamed Ali, Soo Khee Chee, Gan Yik Yuen, Malini Olivo, Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells. Journal of Photochemistry and Photobiology B-biology. ,vol. 65, pp. 59- 73 ,(2001) , 10.1016/S1011-1344(01)00252-4
George A. Kraus, Weijiang Zhang, Michael J. Fehr, Jacob W. Petrich, Yvonne Wannemuehler, Susan Carpenter, Research at the Interface between Chemistry and Virology: Development of a Molecular Flashlight. Chemical Reviews. ,vol. 96, pp. 523- 536 ,(1996) , 10.1021/CR9500139
Sehoon Kim, Tymish Y. Ohulchanskyy, Haridas E. Pudavar, Ravindra K. Pandey, Paras N. Prasad, Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. Journal of the American Chemical Society. ,vol. 129, pp. 2669- 2675 ,(2007) , 10.1021/JA0680257
Yi Sun, Yuan-Jun Hou, Qian-Xiong Zhou, Jing-Rong Chen, Bao-Wen Zhang, Xue-Song Wang, A new Co(III)-hypocrellin B complex with enhanced photonuclease activity. Journal of Inorganic Biochemistry. ,vol. 105, pp. 978- 984 ,(2011) , 10.1016/J.JINORGBIO.2011.03.021
Shenjun Diwu, Cailan Zhang, J.William Lown, Photosensitization with anticancer agents 13. The production of singlet oxygen by halogenated and metal-ion-chelated perylenequinones Journal of Photochemistry and Photobiology A: Chemistry. ,vol. 66, pp. 99- 112 ,(1992) , 10.1016/1010-6030(92)85123-C
Yi-Zhen Hu, Jing-Yi An, Li-Jin Jiang, De-Wen Chen, Spectroscopic study on the photoreduction of hypocrellin A: generation of semiquinone radical anion and hydroquinone Journal of Photochemistry and Photobiology A-chemistry. ,vol. 89, pp. 45- 51 ,(1995) , 10.1016/1010-6030(95)04042-E
Jiahong Zhou, Jihua Liu, Shengqin Xia, Xuesong Wang, Baowen Zhang, Effect of chelation to lanthanum ions on the photodynamic properties of hypocrellin A. Journal of Physical Chemistry B. ,vol. 109, pp. 19529- 19535 ,(2005) , 10.1021/JP0522563
Jiahong Zhou, Lin Zhou, Chao Dong, Yuying Feng, Shaohua Wei, Jian Shen, Xuesong Wang, Preparation and photodynamic properties of water-soluble hypocrellin A-silica nanospheres Materials Letters. ,vol. 62, pp. 2910- 2913 ,(2008) , 10.1016/J.MATLET.2008.01.126