High-efficiency loading of hypocrellin B on graphene oxide for photodynamic therapy
作者： Lin Zhou , Huijun Jiang , Shaohua Wei , Xuefeng Ge , Jiahong Zhou
DOI: 10.1016/J.CARBON.2012.08.013
关键词: Materials science 、 Graphene 、 Stereochemistry 、 Singlet oxygen 、 In vitro 、 Oxide 、 Cytosol 、 Irradiation 、 Photochemistry 、 Stacking 、 Photodynamic therapy
摘要: Abstract A novel hybrid of graphene oxide (GO) and hypocrellin B (HB) was prepared using a simple noncovalent method. An efficient loading HB on GO as high 2 mg/mg obtained. Mechanism analysis indicated that the π–π stacking interaction is dominant driving force in between GO. Irradiation (HB–GO) results generation singlet oxygen (1O2). In vitro studies have demonstrated active uptake HB–GO into cytosol tumor cells. Significant damage to such impregnated cells observed upon irradiation.
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