Optimization of singlet oxygen production from photosensitizer-incorporated, medically relevant hydrogels.
作者： Áine T. De Baróid , Colin P. McCoy , Rebecca A. Craig , Louise Carson , Gavin P. Andrews
DOI: 10.1002/JBM.B.33562
关键词:
摘要: Photodynamic therapy and photodynamic antimicrobial chemotherapy are widely used, but despite this, the relationships between fluence, wavelength of irradiation singlet oxygen (1 O2 ) production poorly understood. To establish these factors in medically relevant materials, effect fluence on 1 from a tetrakis(4-N-methylpyridyl)porphyrin (TMPyP)-incorporated 2-hydroxyethyl methacrylate: methyl methacrylic acid (HEMA: MMA:MAA) copolymer, total energy 50.48 J/cm2 , was applied at varying illumination power, times. characterized using anthracene-9,10-dipropionic acid, disodium salt (ADPA) recently described method. Using two light sources, white LED array halogen source, found to produce less than source when same power (over 500 - 600 nm) time conditions were applied. Importantly, it showed that longest Q band (590 is primarily responsible for generation, linear relationship exists increasing oxygen. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 320-326, 2017.
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