Modulating the photo-exciting process of photosensitizer to improve in vitro phototoxicity by preparing its self-assembly nanostructures

作者: Lin Zhou , Xuefeng Ge , Jiahong Zhou , Shaohua Wei , Jian Shen

DOI: 10.1039/C4RA12855A

关键词:

摘要: A series of hypocrellin (HA) self-assembled nanostructures were prepared by controlling the charge properties drugs and ion strength environment. Comparative studies with HA have demonstrated that effect on molecule significantly enhances its water dispersion ability, 1O2 generation efficiency and, thereby, in vitro phototoxicity to human cervical carcinoma (HeLa) cells.

参考文章(51)
João Paulo Tardivo, Auro Del Giglio, Carla Santos de Oliveira, Dino Santesso Gabrielli, Helena Couto Junqueira, Dayane Batista Tada, Divinomar Severino, Rozane de Fátima Turchiello, Mauricio S. Baptista, Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications. Photodiagnosis and Photodynamic Therapy. ,vol. 2, pp. 175- 191 ,(2005) , 10.1016/S1572-1000(05)00097-9
X. Gao, H. Matsui, Peptide-Based Nanotubes and Their Applications in Bionanotechnology. Advanced Materials. ,vol. 17, pp. 2037- 2050 ,(2005) , 10.1002/ADMA.200401849
Sergey Yu Vasilchenko, Anna I Volkova, Anastasiya V Ryabova, Victor B Loschenov, Vitaly I Konov, Adil A Mamedov, Sergey G Kuzmin, Evgeniy A Lukyanets, None, Application of aluminum phthalocyanine nanoparticles for fluorescent diagnostics in dentistry and skin autotransplantology. Journal of Biophotonics. ,vol. 3, pp. 336- 346 ,(2010) , 10.1002/JBIO.200900099
Sila Toksoz, Handan Acar, Mustafa O. Guler, Self-assembled one-dimensional soft nanostructures Soft Matter. ,vol. 6, pp. 5839- 5849 ,(2010) , 10.1039/C0SM00121J
Lin Zhou, Huijun Jiang, Shaohua Wei, Xuefeng Ge, Jiahong Zhou, Jian Shen, High-efficiency loading of hypocrellin B on graphene oxide for photodynamic therapy Carbon. ,vol. 50, pp. 5594- 5604 ,(2012) , 10.1016/J.CARBON.2012.08.013
Lin Zhou, Shaohua Wei, Xuefeng Ge, Jiahong Zhou, Boyang Yu, Jian Shen, External heavy-atomic construction of photosensitizer nanoparticles for enhanced in vitro photodynamic therapy of cancer. Journal of Physical Chemistry B. ,vol. 116, pp. 12744- 12749 ,(2012) , 10.1021/JP305137J
Fei Ma, Heyong Huang, Xuefeng Ge, Xiaodi Yang, Chao Yang, Lina Han, Jiahong Zhou, Lin Zhou, Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study Bioorganic & Medicinal Chemistry Letters. ,vol. 23, pp. 1689- 1692 ,(2013) , 10.1016/J.BMCL.2013.01.059
Fei Ma, He-Yong Huang, Lin Zhou, Chao Yang, Jia-Hong Zhou, Zheng-Ming Liu, Study on the conformation changes of Lysozyme induced by Hypocrellin A: the mechanism investigation. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. ,vol. 97, pp. 1159- 1165 ,(2012) , 10.1016/J.SAA.2012.07.136
Lin Zhou, Ji-Hua Liu, Jian Zhang, Shao-Hua Wei, Yu-Ying Feng, Jia-Hong Zhou, Bo-Yang Yu, Jian Shen, A new sol-gel silica nanovehicle preparation for photodynamic therapy in vitro. International Journal of Pharmaceutics. ,vol. 386, pp. 131- 137 ,(2010) , 10.1016/J.IJPHARM.2009.11.010
Sehoon Kim, Tymish Y. Ohulchanskyy, Haridas E. Pudavar, Ravindra K. Pandey, Paras N. Prasad, Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. Journal of the American Chemical Society. ,vol. 129, pp. 2669- 2675 ,(2007) , 10.1021/JA0680257