Experimental models of schizophrenia.

摘要: The Kraepelinian subtypes, developed early in the century, recognize heterogeneity of schizophrenia but do not reliably predict differences response to classical neuroleptics. newer distinction positive and negative syndromes carry promise as an approach identifying meaningful clinical neurobiological dimensions. present review summarizes supportive evidence from a series investigations using Positive Negative Syndrome Scale (PANSS), hypothesis on pathophysiology symptoms is advanced.Our data suggest that: (a) represent stable, independent dimensions co-exclusive subtypes; (b) both are unrelated progression illness; (c) they differentially related fundamental aspects schizophrenia, including premorbid adjustment, cognitive development, family psychiatric history, neuropsychiatric profiles, dopaminergic functions, drug res...