Preventing T cell rejection of pig xenografts

摘要: Xenotransplantation is a potential solution to the limited supply of donor organs. While early barriers xenograft acceptance, such as hyperacute rejection, are now largely avoided through genetic engineering, next frontier in successful survival will require prevention T cell-mediated rejection. Most immunosuppressive regimens xenotransplantation utilize cell depletion with antibody therapy. Additionally, use costimulatory blockade - specifically CD40-CD154 pathway shows promise several reports long-term survival. Additional therapies, transgenic expression coinhibitory molecules or transfer immunomodulatory cells promote tolerance, may be necessary achieve reliable acceptance. Further studies pre-clinical models essential order optimize these prior trials patients.