Mouse mammary tumor biology: a short history.

摘要: For over a century, mouse mammary tumor biology and the associated Mouse virus (MMTV) have served as foundation for experimental cancer research, in general, and, particular, breast research. Spontaneous tumors were basis studies of natural history neoplasia, oncogenic viruses, host responses, endocrinology, neoplastic progression. However, lacking formal proof human virus, preeminence model faded 1980s. Since late 1980s, genetically engineered mice (GEM) proven extremely useful studying become animal cancer. Hundreds models been developed since first demonstration, 1984, that gland could be molecularly targeted used to test oncogenicity candidate genes. Now, very few scientists can avoid using their favorite gene. The GEM attracted new generation molecular cellular biologists eager apply skills these surrogates disease. Newcomers often enter field without an appreciation origins many prevailing concepts. Our purpose writing this short is provide historical perspective benefit newcomers. If Einstein was correct “we stand on shoulders giants,” neophytes should meet giants.