Subcortical grey matter changes in untreated, early stage Parkinson's disease without dementia

摘要: Abstract Background Previous MRI studies have investigated cortical or subcortical grey matter changes in patients with Parkinson's disease (PD), yielding inconsistent findings between the studies. We therefore sought to determine whether focal may be present from early stage. Methods recruited 49 untreated, stage PD without dementia and 53 control subjects. Voxel-based morphometry was used evaluate changes, automated volumetry shape analysis were assess volume deformation of structures, respectively. Results showed neither reductions nor increases compared controls. Compared controls, had significant adjusted volumes putamen, nucleus accumbens, hippocampus (corrected p Conclusions Our results suggest that is associated reduction matter, but not reduction. structural posterolateral putamen ventromedial putamen/nucleus accumbens could provide neuroanatomical basis for involvement motor limbic striatum, further implicating non-motor symptoms PD, Early hippocampal might related risk developing patients.