SOX2 amplification is a common event in squamous cell carcinomas of different organ sites

摘要: Acquired chromosomal aberrations, including gene copy number alterations, are involved in the development and progression of human malignancies. SOX2, a transcription factor-coding located at 3q26.33, is known to be recurrently specifically amplified squamous cell carcinomas lung, esophagus, oral cavity. In these organs, SOX2 protein plays an important role tumorigenesis tumor survival. The aim this study was determine whether amplification also found other organs commonly affected by entity. addition, we examined large spectrum lung cancer entities with neuroendocrine differentiation (ie, small cancers, typical atypical carcinoids) for TTF1 gains reveal potential molecular ties or adenocarcinomas lung. Applying fluorescence situ hybridization, assessed cervix uteri (n = 47), skin 57), penis 53) alterations detected amplifications 28%, 32% tumors, respectively. Furthermore, performed immunohistochemical staining that significantly associated overexpression corresponding (P < .001). Of differentiation, only cancers exhibited significant frequencies, indicating least subset might dedifferentiated forms We conclude consequent may represent mechanisms initiation considerable carcinomas.