Low lead exposure from birth produces behavioral toxicity (DRL) in monkeys
作者： Deborah C. Rice , Steven G. Gilbert
DOI: 10.1016/0041-008X(85)90386-2
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摘要: Abstract Cynomolgus monkeys ( Macaca fascicularis ) were dosed from birth with 100, 50, or 0 μg/kg/day of lead. This treatment resulted in blood lead concentrations 25, 15, 3 μg/dl, respectively, before withdrawal infant formula at 200 days age, and steady-state 13, 11 μg/dl. At approximately years tested on an intermittent schedule, differential reinforcement low rate (DRL). schedule required the monkey to withhold responding for a specific time order be reinforced. The performance treated did not improve as rapidly controls measured by increase reinforced responses decrease nonreinforced during initial sessions. In addition, exhibited greater between session variability terminal These effects dose related. results present experiment conjunction those previous experiments this same group suggest that presently found routinely human population may produce neurotoxicity.
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