Selected micronutrients and oral and pharyngeal cancer.

摘要: The relation between selected micronutrients and oral pharyngeal cancer risk was investigated using data from a case-control study conducted January 1992 November 1997 in Italy Switzerland. Cases were 754 incident, histologically confirmed cancers (344 of the cavity 410 pharynx) admitted to major teaching general hospitals areas. Controls 1,775 subjects with no history same catchment areas for acute, non-neoplastic diseases. Dietary habits validated food-frequency questionnaire. Odds ratios (ORs) computed after allowance age, sex, center, education, occupation, body mass index, smoking drinking non-alcohol energy intake. Micronutrients analyzed both as continuous variables quintiles. In former case, unit set 1 SD distribution controls. ORs analysis 0.95 retinol, 0.61for carotene, 0.91 lycopene, 0.83 vitamin D, 0.74 E, 0.63 C, 0.82 thiamine, 0.87for riboflavin, 0.59 B6, 0.61 folic acid, 0.62 niacin, calcium, 0.88 phosphorus, 0.65 potassium, iron, 0.67 iron 0.89 zinc; 95% confidence interval excluded one C potassium iron. similar 2 sexes strata age. When combined intake vitamins E carotene considered, protective effect each nutrient more marked or restricted low other 2. association independent habits, while that less evident those heavily exposed alcohol tobacco. general, micronutrient correlated total vegetable fruit intake, stronger its against cancer. Int. J. Cancer 86:122–127, 2000. © 2000 Wiley-Liss, Inc.