Modeling myeloproliferative neoplasms: From mutations to mouse models and back again
作者： Alessandro Morotti , Stefania Rocca , Giovanna Carrà , Giuseppe Saglio , Mara Brancaccio
DOI: 10.1016/J.BLRE.2016.11.004
关键词:
摘要: Myeloproliferative neoplasms (MPNs) are defined according to the 2008 World Health Organization (WHO) classification and recent 2016 revision. Over years, several genetic lesions have been associated with development of MPNs, important consequences for identifying unique biomarkers specific developing targeted therapies. Defining genotype-phenotype relationship in MPNs is essential identify driver somatic mutations that promote MPN maintenance order develop curative While studies human samples can putative mutations, murine models mandatory demonstrate causative role pre-clinical testing therapeutic interventions. This review focuses on mouse specifically developed assess pathogenetic roles gene found patients, as well MPN-like phenotypes identified genetically modified mice.
sci-hub.se 参考文章(140)
Anthony J Bench, , Elisabeth P Nacheva, Tracey L Hood, Jane L Holden, Lisa French, Soheila Swanton, Kim M Champion, Juan Li, Pamela Whittaker, George Stavrides, Adrienne R Hunt, Brian JP Huntly, Lynda J Campbell, David R Bentley, Panos Deloukas, Anthony R Green, Chromosome 20 deletions in myeloid malignancies: reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genes. UK Cancer Cytogenetics Group (UKCCG). Oncogene. ,vol. 19, pp. 3902- 3913 ,(2000) , 10.1038/SJ.ONC.1203728
H Kitayama, Y Kanakura, T Furitsu, T Tsujimura, K Oritani, H Ikeda, H Sugahara, H Mitsui, Y Kanayama, Y Kitamura, Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood. ,vol. 85, pp. 790- 798 ,(1995) , 10.1182/BLOOD.V85.3.790.BLOODJOURNAL853790
Federica Fusella, Roberta Ferretti, Daniele Recupero, Stefania Rocca, Augusta Di Savino, Giusy Tornillo, Lorenzo Silengo, Emilia Turco, Sara Cabodi, Paolo Provero, Pier Paolo Pandolfi, Anna Sapino, Guido Tarone, Mara Brancaccio, Morgana acts as a proto‐oncogene through inhibition of a ROCK–PTEN pathway The Journal of Pathology. ,vol. 234, pp. 152- 163 ,(2014) , 10.1002/PATH.4341
Mylène Tajan, Audrey de Rocca Serra, Philippe Valet, Thomas Edouard, Armelle Yart, SHP2 sails from physiology to pathology. European Journal of Medical Genetics. ,vol. 58, pp. 509- 525 ,(2015) , 10.1016/J.EJMG.2015.08.005
Radek C. Skoda, Adrian Duek, Jean Grisouard, Pathogenesis of myeloproliferative neoplasms Experimental Hematology. ,vol. 43, pp. 599- 608 ,(2015) , 10.1016/J.EXPHEM.2015.06.007
Wei An, Scott A Nadeau, Bhopal C Mohapatra, Dan Feng, Neha Zutshi, Matthew D Storck, Priyanka Arya, James E Talmadge, Jane L Meza, Vimla Band, Hamid Band, None, Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy. Oncotarget. ,vol. 6, pp. 10498- 10509 ,(2015) , 10.18632/ONCOTARGET.3403
T. Gülen, H. Hägglund, B. Dahlén, G. Nilsson, Mastocytosis: the puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease. Journal of Internal Medicine. ,vol. 279, pp. 211- 228 ,(2016) , 10.1111/JOIM.12410
Animesh Pardanani, Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management. American Journal of Hematology. ,vol. 87, pp. 401- 411 ,(2012) , 10.1002/AJH.23134
Stefan Heinrichs, Lillian F Conover, Carlos E Bueso-Ramos, Outi Kilpivaara, Kristen Stevenson, Donna Neuberg, Mignon L Loh, Wen-Shu Wu, Scott J Rodig, Guillermo Garcia-Manero, Hagop M Kantarjian, A Thomas Look, MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy eLife. ,vol. 2, ,(2013) , 10.7554/ELIFE.00825
C. M. Kiekhaefer, J. A. Grass, K. D. Johnson, M. E. Boyer, E. H. Bresnick, Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 14309- 14314 ,(2002) , 10.1073/PNAS.212389499