SHP2 sails from physiology to pathology.

作者: Mylène Tajan , Audrey de Rocca Serra , Philippe Valet , Thomas Edouard , Armelle Yart

DOI: 10.1016/J.EJMG.2015.08.005

关键词:

摘要: … In the second part, we describe the different PTPN11 mutation-… explain SHP2's negative role in the PI3K/AKT pathway. Indeed… insulin resistance upon a high fat diet, which could directly …

参考文章(231)
Kun-Wei Liu, Haizhong Feng, Robert Bachoo, Andrius Kazlauskas, Erin M. Smith, Karen Symes, Ronald L. Hamilton, Motoo Nagane, Ryo Nishikawa, Bo Hu, Shi-Yuan Cheng, SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans Journal of Clinical Investigation. ,vol. 121, pp. 905- 917 ,(2011) , 10.1172/JCI43690
William E Tidyman, Katherine A Rauen, The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation Current Opinion in Genetics & Development. ,vol. 19, pp. 230- 236 ,(2009) , 10.1016/J.GDE.2009.04.001
A. M. Bennett, T. L. Tang, S. Sugimoto, C. T. Walsh, B. G. Neel, Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 7335- 7339 ,(1994) , 10.1073/PNAS.91.15.7335
Jacqueline A. Noonan, Hypertelorism With Turner Phenotype American Journal of Diseases of Children. ,vol. 116, pp. 373- 380 ,(1968) , 10.1001/ARCHPEDI.1968.02100020377005
Atilano Carcavilla, José L. Santomé, Isabel Pinto, Jaime Sánchez-Pozo, Encarna Guillén-Navarro, María Martín-Frías, Pablo Lapunzina, Begoña Ezquieta, Síndrome LEOPARD: una variante del síndrome de Noonan con fuerte asociación a miocardiopatía hipertrófica Revista Espanola De Cardiologia. ,vol. 66, pp. 350- 356 ,(2013) , 10.1016/J.RECESP.2012.09.017
Huai-Sheng Lu, Yasuhiro Saito, Mayumi Umeda, Naoko Murata-Kamiya, Hong-Mei Zhang, Hideaki Higashi, Masanori Hatakeyama, Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA Cancer Science. ,vol. 99, pp. 2004- 2011 ,(2008) , 10.1111/J.1349-7006.2008.00950.X
Nazilla Alderson, Liping Qiao, Lina Ma, Helen H. Zhu, Zhao He, Kelly Suino-Powell, Kaihong Ji, Jiefu Li, Jianhua Shao, H. Eric Xu, Tiangang Li, Gen-Sheng Feng, Shuangwei Li, Diane D.F. Hsu, Bing Li, Xiaolin Luo, Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metabolism. ,vol. 20, pp. 320- 332 ,(2014) , 10.1016/J.CMET.2014.05.020
Jianxiu Yu, Rong Deng, Helen H. Zhu, Sharon S. Zhang, Changhong Zhu, Marc Montminy, Roger Davis, Gen-Sheng Feng, Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1 and SH2-tyrosine phosphatase Shp2 Journal of Biological Chemistry. ,vol. 288, pp. 3823- 3830 ,(2013) , 10.1074/JBC.M112.397885
Mara Fornaro, Peter M. Burch, Wentian Yang, Lei Zhang, Claire E. Hamilton, Jung H. Kim, Benjamin G. Neel, Anton M. Bennett, SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth Journal of Cell Biology. ,vol. 175, pp. 87- 97 ,(2006) , 10.1083/JCB.200602029
M. Golam Mohi, Ifor R. Williams, Charles R. Dearolf, Gordon Chan, Jeffery L. Kutok, Sarah Cohen, Kelly Morgan, Christina Boulton, Hirokazu Shigematsu, Heike Keilhack, Koichi Akashi, D. Gary Gilliland, Benjamin G. Neel, Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations Cancer Cell. ,vol. 7, pp. 179- 191 ,(2005) , 10.1016/J.CCR.2005.01.010