Baculovirus as versatile vectors for protein expression in insect and mammalian cells

作者: Thomas A Kost , J Patrick Condreay , Donald L Jarvis

DOI: 10.1038/NBT1095

关键词:

摘要: Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to membrane-bound have been successfully produced in baculovirus-infected insect cells. Yet, addition its value producing proteins cells and larvae, this viral vector system continues evolve new unexpected ways. This is exemplified by the development engineered cell lines mimic mammalian glycosylation expressed baculovirus display strategies application virus as a mammalian-cell gene delivery vector. Novel design engineering approaches will serve further enhance technology.

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