The use of virus-like particles for gene transfer.

摘要: Abstract A major challenge in the field of gene therapy is development new carrier/delivery systems that lack disadvantages current transfer systems. In past, some time has been spent developing such modified or alternative vectors. candidate represented by virus-like particles (VLPs). It shown recombinant expression structural proteins many viruses leads to formation VLPs. Such VLPs exhibit morphology similar empty capsids virus from which they are derived. non-infectious, have a tropism natural virus, and show comparable cellular uptake intracellular trafficking. Since its discovery, VLP technology gained importance biomedical research. Although most investigations into dealt with vaccine development, research groups demonstrated could also represent useful delivery system. This review will focus on studies performed members Papillomaviridae Polyomaviridae families.